• Write about Obesity pandemic : obesity definition , BMI classifications, obesity causes, diseases associated with it, obesity prevalence % worldwide and in the united kingdom , how obesity is UK burden, how much its cost the National health service (NHS), economic consequences:, , how affecting negatively the quality of life /health, psychological consequences of it. Suggested prevention interventions : lifestyle changes: 1) Physical activity 2) high fibre diet .
-Physical activity : definition, types aerobic , anaerobic, recommendation for adults world wide and in the united kingdom, health benefits of physical activity. The effect of a single bout of aerobic exercise on subjective appetite. Energy metabolism: Energy expenditure, energy balance definitions. Appetite regulation.
– sedentary lifestyle/behaviour : definition , types.
• Sedentary behaviour: definition, types, prevalence.
• Synergistic effect /combination effect of physical activity and dietary fibre
-Dietary fibre : definition , types (soluble- digestible / insoluble- indigestible) with examples , health benefits , recommended intake , Effect of dietary fibre on non-communicable diseases and current intakes (globally and in the UK). Fermentable dietary fibre: Definition, Effect of fermentable dietary fibre on body weight.
-Short-Chain Fatty Acids (SCFA): definition , types (acetate, propionate, butyrate ), dietary sources, uses, Microbial-derived SCFA ,absorption and transport, metabolism, mechanism (metabolic pathways) for each propionate, acetate, butyrate, SCFA concentrations in human blood, receptors (GPR43 and GPR41 now termed FFAR-2 (free fatty acid receptor 2) and FFAR-3 (free fatty acid receptor 3) respectively. The role of propionate on energy metabolism, expand more on propionate health benefits and it was used with Inulin propionate ester (IPE) colonic delivery should be released only when the inulin ‘carrier molecule’ is fermented in the colon, providing targeted delivery of propionate to its natural site of production.
• Make a figure of Gut derived SCFA metabolic pathways.
• Make diagram Signalling pathways involved in appetite regulation.
provide list of references at the end.
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